RT Journal Article
T1 Dietary Cocoa Prevents Aortic Remodeling and Vascular Oxidative Stress in Diabetic Rats
A1 Álvarez Cilleros, David
A1 López-Oliva Muñoz, María Elvira
A1 Morales Cano, Daniel
A1 Barreira  Barba, Bianca
A1 Pérez Vizcaíno, Francisco
A1 Goya, Luis
A1 Ramos, Sonia
A1 Martín, María Ángeles
AB ScopeThe aim of the present study is to investigate the potential protective effect of a cocoa‐rich diet on functional and structural vascular alterations in diabetes and the mechanism involved.Methods and resultsMale Zucker diabetic fatty (ZDF) rats are fed on a standard (ZDF‐C) or cocoa‐rich diet (ZDF‐Co) from week 10 to 20 of life. Diabetic ZDF‐C rats showed increased blood pressure and enhanced aortic stiffness, as demonstrated by the increased pulse pressure and the augmented aortic medial thickness with loss and disruption of elastic fibres. Interestingly, cocoa intake strongly avoided all these adverse effects and reduced aortic oxidative stress. Mechanistically, cocoa diet prevented sirtuin‐1 (SIRT‐1) depletion and increased NADPH oxidases (NOXs) and reactive oxygen species production as well as reduced active nuclear factor E2 related factor 2 (Nrf2) and their antioxidant products.ConclusionThe results demonstrate for the first time that a cocoa‐rich diet strongly prevents aortic stiffening and remodeling in diabetic animals and avoids aortic oxidative stress. It is suggested that this effect could be mediated via its effects on SIRT‐1, NOXs, and Nrf2.
PB Wiley
SN 1613-4125
YR 2019
FD 2019-06-12
LK https://hdl.handle.net/20.500.14352/109016
UL https://hdl.handle.net/20.500.14352/109016
LA eng
NO Álvarez-Cilleros D, López-Oliva ME, Morales-Cano D, Barreira B, Pérez-Vizcaíno F, Goya L, Ramos S, Martín MÁ. Dietary Cocoa Prevents Aortic Remodeling and Vascular Oxidative Stress in Diabetic Rats. Mol Nutr Food Res. 2019 Sep;63(18):e1900044. doi: 10.1002/mnfr.201900044. Epub 2019 Jun 12. PMID: 31144780.
NO Fondos FEDER
NO European Commission
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 6 abr 2025