RT Journal Article
T1 Particle beam radiobiology status and challenges: a PTCOG radiobiology subcommittee report
A1 Ahmad, Reem
A1 Barcellini, Amelia
A1 Baumann, Kilian
A1 Benje, Malte
A1 Bender, Tamara
A1 Bragado Domingo, Paloma
A1 Gutiérrez Uzquiza, Álvaro
A1 Sánchez Parcerisa, Daniel
A1 Vandevoorde, Charlot
A1 von Neubeck, Cläre
AB Particle therapy (PT) represents a significant advancement in cancer treatment, precisely targeting tumor cells while sparing surrounding healthy tissues thanks to the unique depth-dose profiles of the charged particles. Furthermore, their linear energy transfer and relative biological effectiveness enhance their capability to treat radioresistant tumors, including hypoxic ones. Over the years, extensive research has paved the way for PT's clinical application, and current efforts aim to refine its efficacy and precision, minimizing the toxicities. In this regard, radiobiology research is evolving toward integrating biotechnology to advance drug discovery and radiation therapy optimization. This shift from basic radiobiology to understanding the molecular mechanisms of PT aims to expand the therapeutic window through innovative dose delivery regimens and combined therapy approaches. This review, written by over 30 contributors from various countries, provides a comprehensive look at key research areas and new developments in PT radiobiology, emphasizing the innovations and techniques transforming the field, ranging from the radiobiology of new irradiation modalities to multimodal radiation therapy and modeling efforts. We highlight both advancements and knowledge gaps, with the aim of improving the understanding and application of PT in oncology.
PB Elsevier
YR 2024
FD 2024-09
LK https://hdl.handle.net/20.500.14352/136625
UL https://hdl.handle.net/20.500.14352/136625
LA eng
NO Ahmad, Reem, et al. «Particle Beam Radiobiology Status and Challenges: A PTCOG Radiobiology Subcommittee Report». International Journal of Particle Therapy, vol. 13, septiembre de 2024, p. 100626. DOI.org (Crossref), https://doi.org/10.1016/j.ijpt.2024.100626.
NO Artículo firmado por 32 autores.© 2024 The Authors
NO Helmholtz Centre for Heavy Ion Research
DS Docta Complutense
RD 21 may 2026