TY  - JOUR
AU  - Aguilar Mora, Fabio
AU  - Moshage, Han
AU  - Buist-Homan, Manon
AU  - Geng, Yana
AU  - Schmidt, Martina
AU  - Lezoualc'H, Frank
AU  - Cheng, Xiaodong
AU  - Soto, Juan M.
AU  - Rodrigo Martín-Romo, José Augusto
AU  - Alieva Krasheninnikova, Tatiana
PY  - 2021
DO  - 10.1016/j.biopha.2021.112072
SN  - 0753-3322
UR  - https://hdl.handle.net/20.500.14352/4532
T2  - Biomedicine & pharmacotherapy
AB  - Background and purpose: It has been shown that the antidiabetic drug metformin protects hepatocytes against toxicity by various stressors. Chronic or excessive consumption of diclofenac (DF) - a pain-relieving drug, leads to drug-induced liver injury...
LA  - eng
PB  - Elsevier
KW  - Camp-binding protein
KW  - Induced liver-injury
KW  - Refractive-index
KW  - Cyclic-amp
KW  - Inhibition
KW  - Apoptosis
KW  - Pharmacokinetics
KW  - Phosphorylation
KW  - Activation
KW  - Identification
TI  - Metformin protects against diclofenac-induced toxicity in primary rat hepatocytes by preserving mitochondrial integrity via a pathway involving EPAC
TY  - journal article
VL  - 143
ER  -