RT Journal Article
T1 Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae
A1 Cannatelli, Antonio
A1 Santos López, Alfonso
A1 Giani, Tommaso
A1 González Zorn, Bruno
A1 Rossolini, Gian Maria
AB The inactivation of the mgrB gene, which encodes a negative-feedback regulator of the PhoPQ signaling system, was recently shown to be a common mutational mechanism responsible for acquired polymyxin resistance among carbapenemase-producing Klebsiella pneumoniae strains from clinical sources. In this work, we show that mgrB mutants can easily be selected in vitro from different K. pneumoniae lineages, and mgrB inactivation is not associated with a significant biological cost.
PB American Society for Microbiology
SN 1098-6596
YR 2015
FD 2015-05
LK https://hdl.handle.net/20.500.14352/24678
UL https://hdl.handle.net/20.500.14352/24678
LA eng
NO Unión Europea. FP7
DS Docta Complutense
RD 6 abr 2025