RT Journal Article
T1 Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose
A1 Zekri Nechar, Khaoula
A1 Zamorano León, José J.
A1 Segura Fragoso, Antonio
A1 Alcaide, José R.
A1 Reche, Carmen
A1 Andrés Castillo, Alcira
A1 Martínez Martínez, Carlos H.
A1 Giner, Manel
A1 Jiménez García, Rodrigo
A1 López de Andrés, Ana
A1 Navarro Cuéllar, Carlos
A1 García Fernández, Miguel A.
A1 López Farré, Antonio José
AB (1) Background: This study aimed to analyze if the serum albumin levels of hospitalized SARS-CoV-2 (COVID-19) patients on admission could predict <30 days in-hospital all-cause mortality, and if glucose levels on admission affected this predictive ability.(2) Methods: A multicenter retrospective cohort of 1555 COVID-19-infected adult patients from public hospitals of the Madrid community were analyzed.(3) Results: Logistic regression analysis showed increased mortality for ages higher than 49 y. After adjusting for age, comorbidities and on-admission glucose levels, it was found that on-admission serum albumin ≥3.5 g/dL was significantly associated with reduced mortality (OR 0.48; 95%CI:0.36–0.62). There was an inverse concentration-dependent association between on-admission albumin levels and <30 days in-hospital all-cause mortality. However, when on-admission glucose levels were above 125 mg/dL, higher levels of serum albumin were needed to reach an association with survival. In vitro experiments showed that the spike protein S1 subunit of SARS-CoV-2 binds to native albumin. The binding ability of native albumin to the spike protein S1 subunit was decreased in the presence of an increasing concentration of glycated albumin.(4) Conclusions: On-admission serum albumin levels were inversely associated with <30 days in-hospital all-cause mortality. Native albumin binds the spike protein S1 subunit, suggesting that native albumin may act as a scavenger of the SARS-CoV-2 virus.
PB MPDI
SN 2077-0383
YR 2022
FD 2022-01-25
LK https://hdl.handle.net/20.500.14352/71631
UL https://hdl.handle.net/20.500.14352/71631
LA eng
DS Docta Complutense
RD 1 may 2024