RT Journal Article
T1 Gut-brain chemokine changes in portal hypertensive rats
A1 Merino Martín, José Joaquín
A1 Aller Reyero, María De Los-Ángeles
A1 Rubio, Sandra
A1 Arias, Natalia
A1 Nava Hidalgo, María Paz
A1 Loscertales, Maria
A1 Arias, Jaime
A1 Arias, Jorge-Luis
AB AbstractBackground: Hepatic encephalopathy is a syndrome whose physiopathology is poorly understood; therefore, current diagnostic tests are imperfect and modern therapy is nonspecific. Particularly, it has been suggested that inflammation plays an important role in the pathogenesis of portal hypertensive encephalopathy in the rat.Aim: We have studied an experimental model of portal hypertension based on a triple partial portal vein ligation in the rat to verify this hypothesis.Methods: One month after portal hypertension we assayed in the splanchnic area (liver, small bowel and mesenteric lymph nodes) and in the central nervous system (hippocampus and cerebellum) fractalkine (CX3CL1) and stromal cell-derived factor alpha (SDF1-α) as well as their respective receptors (CX3CR1 and CXCR4) because of their key role in inflammatory processes.Results: The significant increase of fractalkine in mesenteric lymph nodes (P<0.05) and its receptor (CX3CR1) in the small bowel (P<0.05) and hippocampus (P<0.01), associated with the increased expression of SDF1-α in the hippocampus (P<0.01) and the cerebellum (P<0.01) suggest that prehepatic portal hypertension in the rat induces important alterations in the expression of chemokines in the gut-brain axis.Conclusion: The present study revealed that portal hypertension is associated with splanchnic-brain inflammatory alterations mediated by chemokines.
PB SpringerLink
YR 2011
FD 2011-08
LK https://hdl.handle.net/20.500.14352/116761
UL https://hdl.handle.net/20.500.14352/116761
LA eng
NO Merino J, Aller MA, Rubio S, Arias N, Nava MP, Loscertales M, Arias J, Arias JL. Gut-brain chemokine changes in portal hypertensive rats. Dig Dis Sci. 2011 Aug;56(8):2309-17. doi: 10.1007/s10620-011-1625-y. Epub 2011 Feb 24. PMID: 21347560.
DS Docta Complutense
RD 24 abr 2025