%0 Journal Article
%A Arcos Navarrete, Daniel
%A Gómez Cerezo, María Natividad
%A Saiz-Pardo Sanz, Melchor
%A Pablo Velasco, David de
%A Ortega Medina, Luis
%A Enciso, Silvia
%A Fernández Tomé, Blanca
%A Díaz Güemes, Idoia
%A Sánchez Margallo, Francisco Miguel
%A Casarrubios Palomar, Luis
%A Feito Castellano, María José
%A Portolés Pérez, María Teresa
%A Vallet Regí, María Dulce Nombre
%T Injectable mesoporous bioactive nanoparticles regenerate bone tissue under osteoporosis conditions
%D 2022
%@ 1742-7061
%U https://hdl.handle.net/20.500.14352/72100
%X The osteogenic capability of mesoporous bioactive nanoparticles (MBNPs) in the SiO2–CaO system has been assessed in vivo using an osteoporotic rabbit model. MBNPs have been prepared using a double template method, resulting in spherical nanoparticles with a porous core-shell structure that has a high surface area and the ability to incorporate the anti-osteoporotic drug ipriflavone. In vitro expression of the pro-inflammatory genes NF-κB1, IL-6, TNF-α, P38 and NOS2 in RAW-264.7 macrophages, indicates that these nanoparticles do not show adverse inflammatory effects. An injectable system has been prepared by suspending MBNPs in a hyaluronic acid-based hydrogel, which has been injected intraosseously into cavitary bone defects in osteoporotic rabbits. The histological analyses evidenced that MBNPs promote bone regeneration with a moderate inflammatory response. The incorporation of ipriflavone into these nanoparticles resulted in a higher presence of osteoblasts and enhanced angiogenesis at the defect site, but without showing significant differences in terms of new bone formation.
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