RT Journal Article T1 Prognostic value of ki-67 according to age in patients with triple-negative breast cancer A1 Zenzola, Víctor A1 Cabezas-Quintario, , María Antonia A1 Arguelles, Miguel A1 Pérez-Fernández, Elia A1 Izarzugaza, Y A1 Correa, Andrea A1 García-Foncillas, Jesús AB Purpose: The prognostic value of Ki-67 in triple-negative breast cancer (TNBC) is yet unclear because the cut-off points employed differ widely and its predictive effect may vary according to age. The purpose of this study was to analyze the role of Ki-67 among patients with TNBC, and determine the optimal Ki-67 cut-off point to demonstrate its prognostic relevance associated with patient age and treatment strategy.Methods/patients: 201 consecutive patients treated for primary TNBC from 1999 to 2014 were analyzed. Clinicopathological characteristics and outcomes were compared between patients treated with neoadjuvant or adjuvant chemotherapy. We used time-dependent receiver operating characteristic (ROC) curve and time-dependent area under the ROC curve (AUC) to evaluate the discriminative ability of Ki-67 at 3 and 5 years of follow-up. A Ki-67 cut-off point that maximized sensibility and specificity was established. Interaction effect between age and Ki-67 on disease-free survival (DFS) and overall survival (OS) was evaluated by stratified analysis.Results: According to the coordinates of the ROC curves, the best cut-off point for Ki-67 was 60% (high/low). In the whole group, there was not a statistically significant association between Ki-67 and OS and DFS, using a cut-off point of 60%. In multivariate analysis (COX proportional hazards regression), for DFS high Ki-67 (> 60%) was a poor prognostic factor in patients > 40 years old and a better prognostic factor among the patients < 40 years old.Conclusion: Prognostic value of Ki-67 in TNBC, using a cut-off point of 60%, may vary depending on age. PB Springer Link SN 1699-048X SN 1699-3055 YR 2018 FD 2018-04-18 LK https://hdl.handle.net/20.500.14352/116076 UL https://hdl.handle.net/20.500.14352/116076 LA eng NO Zenzola V, Cabezas-Quintario MA, Arguelles M, Pérez-Fernández E, Izarzugaza Y, Correa A, et al. Prognostic value of Ki-67 according to age in patients with triple-negative breast cancer. Clinical and Translational Oncology [Internet]. 2018 Apr 18;20(11):1448–54. Available from: http://dx.doi.org/10.1007/s12094-018-1877-5 DS Docta Complutense RD 28 abr 2025