RT Journal Article
T1 Validation of a brief cross-cultural cognitive screening test in Multiple Sclerosis
A1 Delgado Álvarez, Alfonso
A1 Delgado-Alonso, Cristina
A1 Goudsmit, Miriam
A1 Gil, María José
A1 Díez-Cirarda, María
A1 Valles-Salgado, María
A1 Montero-Escribano, Paloma
A1 Hernández Lorenzo, Laura
A1 Matías-Guiu Guía, Jorge
A1 Matias-Guiu, Jordi A
AB BackgroundSeveral batteries have been developed for the cognitive assessment of people with multiple sclerosis (MS). However, all these tests have some limitations in general clinical practice and from a cross-cultural perspective. In this study, we aimed to validate a novel cognitive screening test, the Cross-Cultural Dementia screening test (CCD), in pwMS.MethodsSeventy-five participants with relapsing-remitting MS and 75 healthy controls were enrolled and completed a comprehensive neuropsychological battery and the CCD. Intergroup comparisons, effect sizes, and correlations with previously validated tests were calculated for a majority and a pilot study of a minority sample. ROC curves were estimated, and random forest classification models were developed.ResultsThere were statistically significant differences between cognitively impaired MS (MS-CI) group and healthy controls, and between MS-CI and non-cognitively impaired MS group in all subtests of CCD with medium to large effect sizes. Correlations with standardized neuropsychological tests were moderate to high, supporting concurrent validity. These results were replicated in the minority sample. The random forest models showed a very accurate classification using the CCD. This test showed good psychometric properties compared with SDMT.ConclusionsOur study validates the CCD for cognitive impairment screening in MS, showing advantages over other routinely used cognitive tests.
PB Elsevier
SN 2211-0348
YR 2022
FD 2022-11
LK https://hdl.handle.net/20.500.14352/104000
UL https://hdl.handle.net/20.500.14352/104000
LA eng
NO Delgado-Álvarez, A., Delgado-Alonso, C., Goudsmit, M., Gil, M. J., Díez-Cirarda, M., Valles-Salgado, M., Montero-Escribano, P., Hernández-Lorenzo, L., Matías-Guiu, J., Matias-Guiu, J. A. (2022). Validation of a brief cross-cultural cognitive screening test in Multiple Sclerosis, Multiple Sclerosis and Related Disorders, 67, 104091. https://doi.org/10.1016/j.msard.2022.104091
NO Instituto de Salud Carlos III
NO European Commission
DS Docta Complutense
RD 23 abr 2025