RT Journal Article
T1 Lymph node dissection in uterine leiomyosarcomas: A matched-pair study
A1 Coronado Martín, Pluvio Jesús
A1 Zapardiel, Ignacio
AB Objective: To assess the impact of the lymph node dissection (LND) in the disease-free (DFS) and overall survival (OS) of the women treated surgically of uterine leiomyosarcoma (ULMS).Material and methods: A multicentric retrospective study was conducted among European countries collecting patients diagnosed of uterine sarcoma (SARcoma of the UTerus - SARCUT study). A total of 390 ULMS were selected for the present study to compare patients who underwent LND and those who did not. A further matched-pair subanalysis identified 116 women, 58 pairs (58 with LND and 58 without it) comparable in age, tumor size, surgical procedures, extrauterine disease and adjuvant treatment. Demographic data, pathology results and follow-up were abstracted from medical records and analyzed. Disease-free (DFS) and overall survival (OS) were studied using Kaplan-Meier curves and Cox regression analysis.Results: Among the 390 patients, the 5-year DFS was significantly higher in no-LDN group comparing to the LDN group (57.7% vs. 33.0%; HR 1.75, 95% CI 1.19-2.56; p = 0.007), but not the 5-year OS (64.6% vs. 64.3%; HR 1,10 95% CI 0,77-1,79; p = 0.704). In the matched-pair subanalysis, there were no statistical differences between the study groups. The 5- year DFS was 50.5% in the no-LND and 33.0% in the LND group (HR 1.38; 95% CI 0,83-2.31; p = 0,218) and the 5-year OS was 59.7% and 64.3% respectively (HR 0.81; 95% CI 0,45-1,49; p = 0,509).Conclusions: LND performed in women diagnosed of ULMS have no impact neither in the disease-free nor in the overall survival compared to patients without LDN in a complete homogeneous group.
PB Elsevier
SN 0090-8258
YR 2023
FD 2023-07-15
LK https://hdl.handle.net/20.500.14352/128896
UL https://hdl.handle.net/20.500.14352/128896
LA eng
NO Coronado PJ, Alonso-Espias M, Yildirim Y, Macuks R, Mancari R, Achimas-Cadariu P, Aniorte SM, Mitidieri M, Lambaudie E, Dubois N, Zapardiel I; SARCUT Study Group. Lymph node dissection in uterine leiomyosarcomas: A matched-pair study. Gynecol Oncol. 2023 Jul;174:28-33. doi: 10.1016/j.ygyno.2023.04.007. Epub 2023 May 3. PMID: 37146437.
DS Docta Complutense
RD 31 dic 2025