%0 Journal Article
%A Díaz, Sara
%A Gutierrez, Sebastian
%A Pérez Velilla, Eduardo
%A Olmos, Ramiro
%A Cabañas Poveda, Albertina
%T Thermodynamic and spectroscopic study of solutions of therapeutic deep eutectic solvents (THEDES) in supercritical CO2
%D 2025
%U https://hdl.handle.net/20.500.14352/116803
%X The solubilities of the Deep Eutectic Solvents (DES) ibuprofen:thymol and ibuprofen:L-menthol in supercritical CO2 were determined up to 250 bar at 40, 50 and 60 °C using a variable volume view cell. The solubility of DES at different compositions was compared to that of the individual components showing little deviation from the linear trend. The vapour-phase compositions for some conditions were also determined by 1H NMR showing that the CO2 preferentially extracts the most volatile component.A FTIR spectroscopic study of the DES at room pressure and the DES dissolved in CO2 was also conducted. At room temperature, ibuprofen was present either forming a dimer or bonded to the terpene. When the DES was dissolved in CO2, significant amounts of free ibuprofen were also found. A simple association model was proposed and some thermodynamic magnitudes were determined. The spectroscopic information is consistent with the thermodynamic data.
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