%0 Journal Article
%A Sevillano Fernández, David
%A Aguilar, Lorenzo
%A Alou Cervera, Luis
%A Gimenez, María José
%A Torrico, Martha
%A González Hidalgo, Natalia
%A Cafini, Fabio
%A Relaño, María Teresa
%A Coronel, Pilar
%A Prieto Prieto, José
%T Urine Bactericidal Activity against Escherichia coli Isolates Exhibiting Different Resistance Phenotypes/Genotypes in an In Vitro Pharmacodynamic Model Simulating Urine Concentrations Obtained after Oral Administration of a 400-Milligram Single Dose of Cefditoren-Pivoxil
%D 2008
%@ 0066-4804
%U https://hdl.handle.net/20.500.14352/107129
%X Activity of simulated cefditoren urinary concentrations was determined against seven Escherichia coli isolates. Bactericidal activity was obtained from 4 to 24 h against TEM-1 (penicillinase production/hyperproduction), TEM-34 (IRT-6), and TEM-116 (extended-spectrum beta-lactamase [ESBL]) and from 6 to 8 h against SHV/TEM-116 (ESBL) but never against SHV/TEM-1 (ESBL). Extension of bactericidal activity depended on the resistance genotype/phenotype tested.
%~