RT Journal Article
T1 Localized and widespread pressure pain hypersensitivity in patients with episodic or chronic migraine: A systematic review and meta-analysis
A1 Fernández de las Peñas, César
A1 Navarro Santana, Marcos J.
A1 Curiel Montero, Francisca
A1 Plaza Manzano, Gustavo
A1 Alburquerque Sendín, Francisco
A1 Rodrigues de Souza, Daiana P.
AB Objective This meta-analysis compared pressure pain sensitivity in trigeminal, cervical spine and remote pain-free areas between migraine patients and headache-free controls considering diagnosis (episodic versus chronic) and sex. Databases and data treatment: Electronic databases were searched for cross-sectional or prospective case-control studies comparing pressure pain thresholds between migraine and headache-free controls. Data were extracted by two reviewers. The risk of bias and methodological quality was assessed by Newcastle-Ottawa Quality Assessment Scale. Meta-analyses of trigeminal, extra-trigeminal (cervical spine) and remote pain-free areas were compared. Frequency of migraine and sex were taken into account. Mean differences (MD) and random effects were calculated. Results Eighteen studies were included. Patients with migraine showed lower pressure pain thresholds than headache-free controls: trigeminal (MD −71.33 kPa, 95%CI −92.14 to −50.53), cervical spine (MD −68.50 kPa, 95%CI −84.67 to −52.33), and remote pain-free (MD −62.49 kPa, 95%CI −99.52 to −25.45) areas. Differences were consistently significant for episodic migraine in all locations, but only significant in the trigeminal area for chronic migraine (MD −67.36 kOPa, 95%CI −101.31 to −33.42). Overall, women had lower pressure pain thresholds than men. The methodological quality of most studies (66.7%) was good. The results showed a high heterogeneity. Conclusion This meta-analysis found low to high quality evidence showing lower pressure pain thresholds in trigeminal, extra-trigeminal, and remote pain-free areas in migraine sufferers when compared with headache-free controls. Hypersensitivity to pressure pain locally and widespread was consistently observed in episodic migraine, but locally in chronic migraine as compared to headache-free controls. Women with migraine were more sensitive than men. Registration number: https://doi.org/10.17605/OSF.IO/YJTAK
PB Sage Publications
SN 0333-1024
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/117931
UL https://hdl.handle.net/20.500.14352/117931
LA eng
NO Fernández-de-las-Peñas C, Navarro-Santana MJ, Curiel-Montero F, Plaza-Manzano G, Alburquerque-Sendín F, Rodrigues-de-Souza DP. Localized and widespread pressure pain hypersensitivity in patients with episodic or chronic migraine: A systematic review and meta-analysis. Cephalalgia. 2022;42(9):966-980. doi:10.1177/03331024221084217
DS Docta Complutense
RD 24 mar 2026