RT Journal Article
T1 Axonal Guidance Using Biofunctionalized Straining Flow Spinning Regenerated Silk Fibroin Fibers as Scaffold
A1 Castro Domínguez, Cristina
A1 Lozano Picazo, Paloma
A1 Alvárez López, Aroa
A1 Garrote Junco, Javier
A1 Panetsos Petrova, Fivos
A1 Guinea Tortuero, Gustavo Víctor
A1 Elices Calafat, Manuel
A1 Rojo Pérez, Francisco Javier
A1 González Nieto, Daniel
A1 Colchero Paetz, Luís
A1 Ramos Gómez, Milagros
A1 Pérez Rigueiro, José
AB After an injury, the limited regenerative capacity of the central nervous system makes the reconnection and functional recovery of the affected nervous tissue almost impossible. To address this problem, biomaterials appear as a promising option for the design of scaffolds that promote and guide this regenerative process. Based on previous seminal works on the ability of regenerated silk fibroin fibers spun through the straining flow spinning (SFS) technique, this study is intended to show that the usage of functionalized SFS fibers allows an enhancement of the guidance ability of the material when compared with the control (nonfunctionalized) fibers. It is shown that the axons of the neurons not only tend to follow the path marked by the fibers, in contrast to the isotropic growth observed on conventional culture plates, but also that this guidance can be further modulated through the biofunctionalization of the material with adhesion peptides. Establishing the guidance ability of these fibers opens the possibility of their use as implants for spinal cord injuries, so that they may represent the core of a therapy that would allow the reconnection of the injured ends of the spinal cord.
PB MDPI
SN 2313-7673
YR 2023
FD 2023-02-04
LK https://hdl.handle.net/20.500.14352/73350
UL https://hdl.handle.net/20.500.14352/73350
LA eng
NO Ministerio de Ciencia e Innovación de España
NO Comunidad de Madrid (España)
NO Banco Santander (España)
NO Universidad Complutense de Madrid (España)
DS Docta Complutense
RD 6 abr 2025