RT Journal Article
T1 Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14
A1 Rodríguez, Ana Eugenia
A1 Hernández, Jose Ángel
A1 Benito, Rocío
A1 Gutiérrez, Norma
A1 García, Juan Luis
A1 Hernández Sánchez, María
A1 Risueño, Alberto
A1 Sarasquete, M. Eugenia
A1 Fermiñán, Encarna
A1 Fisac, Rosa
A1 García de Coca, Alfonso
A1 Martín-Núñez, Guillermo
A1 Heras, Natalia de las
A1 Recio, Isabel
A1 Gutiérrez, Oliver
A1 Rivas, Javier De Las
A1 González, Marcos
A1 Hernández-Rivas, Jesús
AB BackgroundPatients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of 13q-H patients.Design and Methods:A total of 102 samples were studied, 32 of which served as a validation cohort and five were healthy donors.ResultsChronic lymphocytic leukemia patients with higher percentages of 13q- cells (>80%) showed a different level of gene expression as compared to patients with lower percentages (<80%, 13q-L). This deregulation affected genes involved in apoptosis and proliferation (BCR and NFkB signaling), leading to increased proliferation and decreased apoptosis in 13q-H patients. Deregulation of several microRNAs, such as miR-15a, miR-155, miR-29a and miR-223, was also observed in these patients. In addition, our study also suggests that the gene expression pattern of 13q-H cases could be similar to the patients with 11q- or 17p-.ConclusionsThis study provides new evidence regarding the heterogeneity of 13q deletion in chronic lymphocytic leukemia patients, showing that apoptosis, proliferation as well as miRNA regulation are involved in cases with higher percentages of 13q- cells.
PB Public Library of Science
YR 2012
FD 2012
LK https://hdl.handle.net/20.500.14352/93345
UL https://hdl.handle.net/20.500.14352/93345
LA eng
NO Rodríguez AE, Hernández JÁ, Benito R, Gutiérrez NC, García JL, Hernández-Sánchez M, et al. Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14. PLoS ONE 2012;7:e48485. https://doi.org/10.1371/journal.pone.0048485.
NO Ministerio de Sanidad (España)
NO Caja de Burgos
NO Junta de Castilla y León
NO Instituto de Salud Carlos III
NO Ministerio de Ciencias e Innovación (España)
NO Universidad de Salamanca
DS Docta Complutense
RD 24 ago 2024