TY  - JOUR
AU  - Ruiz-de-la-Herrán, Javier
AU  - Tomé-Amat, Jaime
AU  - Lázaro Gorines, Rodrigo
AU  - Gavilanes, José G.
AU  - Lacadena García-Gallo, Francisco Javier
PY  - 2019
DO  - 10.3390/toxins11100593
SN  - 2072-6651
UR  - https://hdl.handle.net/20.500.14352/12352
T2  - Toxins
AB  - Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells. Among them, RNases-based...
AB  - Las inmunotoxinas son moléculas quiméricas que combinan la especificidad de un anticuerpo para reconocer y unir antígenos tumorales con la potencia de la actividad enzimática de una toxina, promoviendo así la muerte de las células diana. Entre ellos,...
LA  - eng
M2  - 593
PB  - mdpi
KW  - immunotoxin
KW  - ribotoxin
KW  - α-sarcin
KW  - RNase T1
KW  - furin
KW  - intracellular trafficking
KW  - colorectal cancer
TI  - Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins
TY  - journal article
VL  - 11
ER  -