RT Journal Article
T1 Characteristic findings in the human fetus vestibule: A human temporal bone study
A1 Honkura, Yohei
A1 Katori, Yukio
A1 Hirano-Kawamoto, Ai
A1 Kawase, Tetsuaki
A1 Rodríguez Vázquez, José Francisco
A1 Murakami, Gen
A1 Abe, Hiroshi
AB ObjectiveThe “collapse,” a highly flexed, dented, or caved membrane between the endo- and peri-lymph of the saccule and utricle in adults, is considered as a morphological aspect of Ménière's syndrome. Likewise, when mesh-like tissues in the perilymphatic space are damaged or lost, the endothelium loses mechanical support and causes nerve irritation. However, these morphologies were not examined in fetuses.MethodsBy using histological sections from 25 human fetuses (crown-rump length[CRL] 82–372 mm; approximately 12–40 weeks), morphologies of the perilymphatic-endolymphatic border membrane and the mesh-like tissue around the endothelium were examined.ResultsThe highly flexed or caved membrane between the endo- and peri-lymphatic spaces was usually seen in the growing saccule and utricle of fetuses, especially at junctions between the utricle and ampulla at midterm. Likewise, the perilymphatic space around the saccule, utricle and semicircular ducts often lost the mesh-like tissues. The residual mesh-like tissue supported the veins, especially in the semicircular canal.ConclusionWithin a cartilaginous or bony room showing a limited growth in size but containing increased perilymph, the growing endothelium appeared to become wavy. Owing to a difference in growth rates between the utricle and semicircular duct, the dentation tended to be more frequently seen at junctions than at free margins of the utricle. The difference in site and gestational age suggested that the deformity was not “pathological” but occurred due to unbalanced growth of the border membrane. Nevertheless, the possibility that the deformed membrane in fetuses was an artifact caused by delayed fixation is not deniable.
PB Elsevier
SN 0385-8146
YR 2024
FD 2024-02
LK https://hdl.handle.net/20.500.14352/108969
UL https://hdl.handle.net/20.500.14352/108969
LA eng
NO Honkura, Y., Katori, Y., Hirano-Kawamoto, A., Kawase, T., Rodríguez-Vázquez, J. F., Murakami, G., & Abe, H. (2024). Characteristic findings in the human fetus vestibule: A human temporal bone study. Auris, nasus, larynx, 51(1), 147–153. https://doi.org/10.1016/j.anl.2023.05.004
DS Docta Complutense
RD 9 abr 2026