RT Journal Article
T1 Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity
A1 Gómez, Alexia
A1 Sánchez-Román Rojas, Inés
A1 Gomez, Jose
A1 Cruces, Julia
A1 Mate, Ianire
A1 López Torres, Mónica
A1 Naudi, Alba
A1 Portero-Otín, Manuel
A1 Pamplona, Reinald
A1 Fuente Del Rey, María Mónica De La
A1 Barja De Quiroga Losada, Gustavo
AB The membrane fatty acid unsaturation hypothesis of aging and longevity is experimentally tested for the first time in mammals. Lifelong treatment of mice with the β1-blocker atenolol increased the amount of the extracellular-signal-regulated kinase signaling protein and successfully decreased one of the two traits appropriately correlating with animal longevity, the membrane fatty acid unsaturation degree of cardiac and skeletal muscle mitochondria, changing their lipid profile toward that present in much more longer-lived mammals. This was mainly due to decreases in 22:6n-3 and increases in 18:1n-9 fatty acids. The atenolol treatment also lowered visceral adiposity (by 24%), decreased mitochondrial protein oxidative, glycoxidative, and lipoxidative damage in both organs, and lowered oxidative damage in heart mitochondrial DNA. Atenolol also improved various immune (chemotaxis and natural killer activities) and behavioral functions (equilibrium, motor coordination, and muscular vigor). It also totally or partially prevented the aging-related detrimental changes observed in mitochondrial membrane unsaturation, protein oxidative modifications, and immune and behavioral functions, without changing longevity. The controls reached 3.93 years of age, a substantially higher maximum longevity than the best previously described for this strain (3.0 years). Side effects of the drug could have masked a likely lowering of the endogenous aging rate induced by the decrease in membrane fatty acid unsaturation. We conclude that it is atenolol that failed to increase longevity, and likely not the decrease in membrane unsaturation induced by the drug.
PB Wiley
SN 1474-9718
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/97789
UL https://hdl.handle.net/20.500.14352/97789
LA eng
NO Gómez, A., Sánchez-Roman, I., Gomez, J., Cruces, J., Mate, I., Lopez-Torres, M., Naudi, A., Portero-Otin, M., Pamplona, R., De la Fuente, M. and Barja, G. (2014), Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity. Aging Cell, 13: 551-560. https://doi.org/10.1111/acel.12205
NO European Commission
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Instituto de Salud Carlos III
NO Universidad Complutense de Madrid
NO Generalitat de Catalunya
NO Ministerio de Sanidad (España)
DS Docta Complutense
RD 18 abr 2025