RT Journal Article
T1 Early exposure to Batrachochytrium dendrobatidis causes profound immunosuppression in amphibians
A1 Fernández-Loras, Andrés
A1 Fernández-Beaskoetxea, Saioa
A1 Arriero Higueras, Elena
A1 Fisher, Matthew C.
A1 Bosch López, Jaime Alfonso
AB Fungal pathogens have evolved a broad suite of strategies aiming at evading the host immune response. Amphibians are globally infected by the panzootic chytrid fungus Batrachochytrium dendrobatidis (Bd) and, while robust innate immune defences have been characterised, there is little evidence for the existence of effective adaptive immunity. We determine the immune response of the common midwife toad following challenge by Bd as larvae. Immune function was described for both the cell-mediated and antibody-mediated immune responses following infectious challenge as larval amphibians. While there were no significant differences in the ratio of neutrophils/lymphocytes between infected and uninfected individuals, early exposure of tadpoles to Bd significantly dampened the levels of circulating immunoglobulins (IgM and IgY) in the serum of juveniles after metamorphosis. Our results show that Bd immunosuppresses amphibians when infection occurs as larvae with potentially broad effects on the remodelling of immunity during metamorphosis.
PB Springer
SN 1612-4642, ESSN: 1439-0574
YR 2017
FD 2017-12
LK https://hdl.handle.net/20.500.14352/18382
UL https://hdl.handle.net/20.500.14352/18382
LA eng
NO Fundación General CSIC (España)-Banco de Santander
NO Leverhulme Trust(UK)
DS Docta Complutense
RD 28 abr 2024