RT Journal Article
T1 An Early Mediterranean-Based Nutritional Intervention during Pregnancy Reduces Metabolic Syndrome and Glucose Dysregulation Rates at 3 Years Postpartum
A1 Melero, Verónica
A1 Arnoriaga, Maria
A1 Barabash Bustelo, Ana
A1 Valerio, Johanna
A1 del Valle, Laura
A1 Martín O'Connor, Rocío
A1 De Miguel Novoa, María De La Paz
A1 Díaz Pérez, José Ángel
A1 Familiar, Cristina
A1 Moraga, Inmaculada
A1 Durán Rodríguez-Hervada, Alejandra
A1 Cuesta, Martín
A1 Torrejón, María José
A1 Martínez Novillo, Mercedes
A1 Moreno, María
A1 Romera, Gisela
A1 Runkle De La Vega, Isabel Ana
A1 Pazos, Mario
A1 Rubio Herrera, Miguel Ángel
A1 Matía Martín, María Del Pilar
A1 Calle Pascual, Alfonso Luis
AB A Mediterranean diet (MedDiet)-based intervention reduces the rate of immediate postpartum maternal metabolic disorders. Whether these effects persist long-term remains to be determined. A total of 2526 normoglycemic women were randomized before the 12th gestational week (GW). IG women followed a MedDiet with extra virgin olive oil (EVOO) (>40 mL/day) and a handful of nuts daily, whereas CG women had to restrict all kinds of dietary fat. At 3 months postpartum, a motivational lifestyle interview was held. The endpoint of the study evaluated the rate of abnormal glucose regulation (AGR) and metabolic syndrome (MetS) at 3 years postpartum in women of the San Carlos cohort. A total of 369/625 (59%) CG women and 1031/1603 (64.3%) IG women were finally analyzed. At 3 months and 3 years postdelivery, the IG women showed higher adherence to the MedDiet, which was associated with lower values of body mass index (BMI) and lipid and glycemic profiles. Body weight change and waist circumference were lower in the IG women. After applying multiple regression analysis, the ORs (95%CI) resulted in AGR (3.18 (2.48–4.08); p < 0.001)/MetS (3.79 (1.81–7.95); p = 0.001) for women with GDM and higher OR for development of MetS in CG women (3.73 (1.77–7.87); p = 0.001). A MedDiet-based intervention early in pregnancy demonstrated persistent beneficial effects on AGR and MetS rates at 3 years postpartum.
PB MDPI
YR 2023
FD 2023-07-22
LK https://hdl.handle.net/20.500.14352/103977
UL https://hdl.handle.net/20.500.14352/103977
LA eng
NO Melero, V., Arnoriaga, M., Barabash, A., Valerio, J., Del Valle, L., Martin O'Connor, R., de Miguel, M. P., Diaz, J. A., Familiar, C., Moraga, I., Duran, A., Cuesta, M., Torrejon, M. J., Martinez-Novillo, M., Moreno, M., Romera, G., Runkle, I., Pazos, M., Rubio, M. A., Matia-Martín, P., … Calle-Pascual, A. L. (2023). An Early Mediterranean-Based Nutritional Intervention during Pregnancy Reduces Metabolic Syndrome and Glucose Dysregulation Rates at 3 Years Postpartum. Nutrients, 15(14), 3252. https://doi.org/10.3390/nu15143252
NO 2023 Descuento MDPI
NO Instituto de Salud Carlos III
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO European Commission
DS Docta Complutense
RD 6 oct 2024