RT Journal Article
T1 Antimicrobial therapy in periodontitis: the use of systemic antimicrobials against the subgingival biofilm
A1 Herrera González, David
A1 Alonso Álvarez, Bettina María
A1 León, Rubén
A1 Roldán, Silvia
A1 Sanz Alonso, Mariano
AB Objectives: The aim was to answer three relevant questions: can systemic antimicrobials be efficacious if the biofilm is not disrupted? Can the type of debridement of the subgingival biofilm impact upon the clinical outcomes of the adjunctive antimicrobial therapy? Is the efficacy of the adjunctive systemic antimicrobial therapy dependent on the quality of the debridement of the subgingival biofilm and the sequence debridement–antibiotic usage?Material and Methods: Relevant papers were searched, critically analysed and their data were extracted.Results: For the first question, studies assessing susceptibility of bacteria in biofilms, and clinical studies evaluating systemic antimicrobials as monotherapy, were reviewed. For the second question, clinical studies comparing systemic antimicrobials as adjuncts to non-surgical debridement or to periodontal surgery and clinical trials using systemic antibiotics with periodontal surgery were evaluated. For the third question, a previous systematic review was updated.Conclusion: If systemic antimicrobials are indicated in periodontal therapy, they should be adjunctive to mechanical debridement. There is not enough evidence to support their use with periodontal surgery. Indirect evidence suggests that antibiotic intake should start on the day of debridement completion, debridement should be completed within a short time (preferably <1 week) and with an adequate quality, to optimize the results.
PB Wiley
SN 0303-6979
YR 2008
FD 2008
LK https://hdl.handle.net/20.500.14352/98383
UL https://hdl.handle.net/20.500.14352/98383
LA eng
NO Herrera D, Alonso B, León R, Roldán S, Sanz M. Antimicrobial therapy in periodontitis: the use of systemic antimicrobials against the subgingival biofilm. J Clin Periodontol. 2008 Sep;35(8 Suppl):45-66.
DS Docta Complutense
RD 18 ago 2024