RT Journal Article
T1 Short‐term efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E on peri‐implant mucositis: A double‐blind, randomized, clinical trial
A1 González Serrano, José
A1 López-Pintor Muñoz, Rosa María
A1 Serrano Valle, Julia
A1 Torres García Denche, Jesús
A1 Hernández Vallejo, Gonzalo
A1 Sanz Martín, Mariano
AB Objective: To determine the efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E as adjuvant to mechanical debridement in the treatment of peri- implant mucositis (PM).Background: Propolis has anti-inflammatory and antibacterial effect that may im- prove peri-implant health.Methods: A randomized, double-blind study was performed on patients with at least one implant with PM. Participants received a professional prophylaxis and were in- structed to use either test or a control gel as toothpaste three times/day for 1 month. Clinical and microbiological parameters were evaluated. PM resolution was considered in absence of bleeding on probing (BOP). Data were analysed with Mann-Whitney U, Wilcoxon signed-rank and chi-square tests.Results: Forty-six patients participated (23 in each group). After treatment, 26.1% of test patients showed complete PM resolution versus 0% in control group (p = .02). Significant reductions were observed in plaque index (p = .03), BOP (p = .04) and prob- ing depths (p = .027) in test compared with control group. The reduction in Tannerella forsythia was statistically greater in test than in control group at 1-month follow-up (p = .02). Porphyromonas gingivalis was statistically reduced in test group from baseline to 1-month follow-up (p = .05).Conclusion: Test gel clinically improved PM and showed certain antimicrobial effect after 1 month in comparison with control group. Further long-term clinical trials are required to confirm these results.
PB Wiley
SN 0022-3484
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/93359
UL https://hdl.handle.net/20.500.14352/93359
LA eng
NO González-Serrano J, López-Pintor RM, Serrano J, Torres J, Hernández G, Sanz M. Short-term efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E on peri-implant mucositis: A double-blind, randomized, clinical trial. J Periodont Res. 2021;56:897–906Short-term efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E on peri-implant mucositis. A double-blind, randomized, clinical trial. Journal of Periodontal Research 2021;. 56(5): 897 - 906
DS Docta Complutense
RD 9 abr 2025