RT Journal Article
T1 Hog1 Controls Lipids Homeostasis Upon Osmotic Stress in Candida albicans
A1 Herrero-de-Dios, Carmen
A1 Román González, Elvira
A1 Pla Alonso, Jesús
A1 Alonso Monge, Rebeca María Del Mar
AB As opportunistic pathogen, Candida albicans adapts to different environmental conditions and its corresponding stress. The Hog1 MAPK (Mitogen Activated Protein Kinase) was identified as the main MAPK involved in the response to osmotic stress. It was later shown that this MAPK is also involved in the response to a variety of stresses and therefore, its role in virulence, survival to phagocytes and establishment as commensal in the mouse gastrointestinal tract was reported. In this work, the role of Hog1 in osmotic stress is further analyzed, showing that this MAPK is involved in lipid homeostasis. The hog1 mutant accumulates lipid droplets when exposed to osmotic stress, leading to an increase in cell permeability and delaying the endocytic trafficking routes. Cek1, a MAPK also implicated in the response to osmotic challenge, did not play a role in lipid homeostasis indicating that Hog1 is the main MAP kinase in this response. The alteration on lipid metabolism observed in hog1 mutants is proposed to contribute to the sensitivity to osmotic stress.
PB MDPI
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/128961
UL https://hdl.handle.net/20.500.14352/128961
LA eng
NO Herrero-de-Dios C, Román E, Pla J, Alonso-Monge R. Hog1 Controls Lipids Homeostasis Upon Osmotic Stress in Candida albicans. Journal of Fungi. 2020; 6(4):355. https://doi.org/10.3390/jof6040355
NO Ministerio de Economía y Competitividad (España)
NO Comunidad de Madrid
DS Docta Complutense
RD 18 mar 2026