RT Journal Article
T1 Modulation of Monoaminergic Systems by Antidepressants in the Frontal Cortex of Rats After Chronic Mild Stress Exposure
A1 Martín Hernández, David
A1 Pereira, Marta
A1 Tendilla, Hiram
A1 Muñoz Madrigal, José Luis
A1 García Bueno, Borja
A1 Leza Cerro, Juan Carlos
A1 Caso Fernández, Javier Rubén
AB The standard pharmacological treatment of the major depressive disorder (MDD) is still grounded in a monoaminergic approach. Consequently, antidepressant treatments pursue to heighten serotonergic and noradrenergic neurotransmissions. Thus, the aim of this study was to assess the impact of exposure to a well-characterized animal model, the chronic mild stress (CMS) on serotonin (5-HT) and noradrenaline (NE) levels, and reuptake transporters and receptors in the frontal cortex (FC) of CMS-exposed rats. Moreover, considering the diverse pharmacological profiles of existing antidepressants and the large number of patients not responding to treatments, we have investigated whether generally utilized antidepressants can modulate their expression. Male Wistar rats were exposed to CMS and some of them treated with desipramine, escitalopram, or duloxetine. Possible changes in the described monoaminergic neurotransmission elements were evaluated. CMS induced differences in the expression of reuptake transporters and receptors involved in the monoaminergic neurotransmission pointing towards the weakening of their signaling. CMS antidepressant-treated rats showed an improvement of the monoaminergic tone, being desipramine and duloxetine more influential than escitalopram over noradrenergic elements and having the three antidepressant-tested effects on serotonergic transmission. In summary, there are molecular alterations on the monoaminergic neurotransmission in FC induced by CMS exposure. Besides, antidepressant treatments modulate the elements of these neurotransmission systems differentially.
PB Springer
SN 0893-7648
YR 2019
FD 2019-05-03
LK https://hdl.handle.net/20.500.14352/109918
UL https://hdl.handle.net/20.500.14352/109918
LA eng
NO Martín-Hernández, D., Pereira, M.P., Tendilla-Beltrán, H. et al. Modulation of Monoaminergic Systems by Antidepressants in the Frontal Cortex of Rats After Chronic Mild Stress Exposure. Mol Neurobiol 56, 7522–7533 (2019). https://doi.org/10.1007/s12035-019-1619-x
DS Docta Complutense
RD 10 abr 2025