RT Journal Article
T1 Post-antifungal effect and effects of sub-MIC concentrations on previously treated Candida spp.: In  uence of exposure time and concentration
A1 García Esteban, María Teresa
A1 Llorente, María Teresa
A1 Mínguez Mínguez, Fernando A.
A1 Prieto Prieto, José
AB This study evaluates the influence of exposure time and concentration on the post-antifungal effect (PAFE) and the effect of sub-MIC concentrations (1/4 × MIC) on Candida albicans and C. glabrata in the PAFE stage (PAFSE). This stage was induced by pretreatment for 1.5, 3 or 12 h with 1 × , 4 × or 8 × MIC of 4 antifungal agents fundamental to modern candidiasis therapy. The length of the 2 effects studied was dependent on the concentration of the antifungal agent applied during pretreatment, as well as on the exposure time. An increase in the dose and/or longer pretreatment prolonged the duration of the PAFE and PAFSE in both species and with all the antifungal agents. Significant PAFEs were always observed for amphotericin B and 5-fluorocytosine (0.8-13 h and 0.6-10.8 h, respectively). These values were increased (by 2.3-8.7 h and 1.5-7.8 h, respectively) by posterior exposure to 1/4 × MIC of the respective antifungal agent. Neither ketoconazole nor fluconazole were able to induce significant PAFEs, even with exposures of up to 12 h duration and a dose of 8 × MIC. However, treatment with 1/4 × MIC of each of the 2 azoles led to significant PAFSEs in both yeast species, of up to 6.5 h duration with ketoconazole and 1.7 h with fluconazole, if the concentrations and/or exposure times were sufficiently high.
PB Taylor & Francis
SN 0036-5548
YR 2002
FD 2002
LK https://hdl.handle.net/20.500.14352/125516
UL https://hdl.handle.net/20.500.14352/125516
LA eng
NO García, Llorente, Mínguez, & Prieto. (2002). Post-antifungal effect and effects of sub-MIC concentrations on previously treated Candida spp.: Influence of exposure time and concentration. Scandinavian Journal of Infectious Diseases, 34(3), 197-200. https://doi.org/10.1080/00365540110080340
DS Docta Complutense
RD 17 abr 2026