RT Journal Article
T1 Factor H-related proteins determine complement-activating surfaces
A1 Mihaly, Jozsi
A1 Tortajada Alonso, Agustín
A1 Uzonyi, Barbara
A1 Goicoechea De Jorge, Elena
A1 Rodriguez de Cordoba, Santiago
AB Complement factor H-related proteins (FHRs) are strongly associated with different diseases involving complement dysregulation, which suggests a major role for these proteins regulating complement activation. Because FHRs are evolutionarily and structurally related to complement inhibitor factor H (FH), the initial assumption was that the FHRs are also negative complement regulators. Whereas weak complement inhibiting activities were originally reported for these molecules, recent developments indicate that FHRs may enhance complement activation, with important implications for the role of these proteins in health and disease. We review these findings here, and propose that FHRs represent a complex set of surface recognition molecules that, by competing with FH, provide improved discrimination of self and non-self surfaces and play a central role in determining appropriate activation of the complement pathway.
YR 2015
FD 2015-06-01
LK https://hdl.handle.net/20.500.14352/114390
UL https://hdl.handle.net/20.500.14352/114390
LA eng
NO Józsi M, Tortajada A, Uzonyi B, Goicoechea de Jorge E, Rodríguez de Córdoba S. Factor H-related proteins determine complement-activating surfaces. Trends Immunol. 2015 Jun;36(6):374-84. doi: 10.1016/j.it.2015.04.008. Epub 2015 May 13. PMID: 25979655.
DS Docta Complutense
RD 6 abr 2025