%0 Journal Article
%A Sanz Esporrin, Javier
%A Di Raimondo, Riccardo
%A Vignoletti, Fabio
%A Núñez, Javier
%A Muñoz, Fernando
%A Sanz Alonso, Mariano
%T De novo bone formation around implants with a surface based on a monolayer of multi‐phosphonate molecules. An experimental in vivo investigation
%D 2021
%@ 0905-7161
%U https://hdl.handle.net/20.500.14352/8634
%X Objectives: The purpose of this experimental in vivo investigation was to evaluate the influence of modifying the implant surface by adding a monolayer of multiphosphonate molecules on the de novo bone formation and osseointegration.Material and Methods: The study was designed as an animal preclinical trial with intra-animal control and two healing periods, 2 and 8 weeks, to compare implants with an identical macro-design but with two different surfaces. Eight female Beagle dogs participated in the study. Control implants had a moderately rough surface combining sandblasting and acid etching; test implants had an additional monophosphonate layer covalently bonded to titanium. Histologic and radiographic (micro-CT) outcome variables were evaluated. Results: The first bone-to-implant contact (fBIC) was located more coronally for the test implants at the first (0.065 mm (95% CI = −0.82, 0.60)) and second healing milestones (0.17 mm (95% CI = −0.9, 0.55)). Most coronal BIC of the test implants displayed a higher percentage of osseointegration, +6.33% and +13.38% after 2 and 8 weeks, respectively; however, the differences were not statistically significant. The micro-CT examination did not show any BIC difference.Conclusions: The monophosphonate layer coating demonstrated clinical, histological, and radiographic results similar to the control surface.
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