RT Journal Article
T1 Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples
A1 Valero, Manuel
A1 Cid, Elena
A1 Averkin, Robert G
A1 Aguilar, Juan
A1 Viney, Tim J
A1 Gómez-Domínguez, Daniel
A1 Bellistri, Elisa
A1 Menéndez de la Prida, Liset
A1 Sánchez-Aguilera López, Alberto
AB Sharp-wave ripples represent a prominent synchronous activity pattern in the mammalian hippocampus during sleep and immobility. GABAergic interneuronal types are silenced or fire during these events, but the mechanism of pyramidal cell (PC) participation remains elusive. We found opposite membrane polarization of deep (closer to stratum oriens) and superficial (closer to stratum radiatum) rat CA1 PCs during sharp-wave ripples. Using sharp and multi-site recordings in combination with neurochemical profiling, we observed a predominant inhibitory drive of deep calbindin (CB)-immunonegative PCs that contrasts with a prominent depolarization of superficial CB-immunopositive PCs. Biased contribution of perisomatic GABAergic inputs, together with suppression of CA2 PCs, may explain the selection of CA1 PCs during sharp-wave ripples. A deep-superficial gradient interacted with behavioral and spatial effects to determine cell participation during sleep and awake sharp-wave ripples in freely moving rats. Thus, the firing dynamics of hippocampal PCs are exquisitely controlled at subcellular and microcircuit levels in a cell type-selective manner.
PB Springer nature
SN 1097-6256
YR 2015
FD 2015-09
LK https://hdl.handle.net/20.500.14352/95138
UL https://hdl.handle.net/20.500.14352/95138
LA eng
DS Docta Complutense
RD 23 abr 2025