RT Journal Article
T1 Genetically engineered mice as a model for studying cardiac arrhythmias
A1 Tamargo Menéndez, Juan
A1 Caballero Collado, Ricardo
A1 Núñez Fernández, Lucía
A1 Gómez García, Ricardo
A1 Vaquero, Miguel
A1 Delpón Mosquera, María Eva
AB Sudden cardiac death due to ventricular tachyarrhythmias remains an unresolved problem, probably because the mechanisms responsible for the progression of cardiac disease to electrophysiological failure are poorly understood. Genetically engineered mice, the principal mammalian model for studying cardiac electrophysiology, have contributed to the understanding of the genetic, molecular and systemic mechanisms involved in the initiation and/or maintenance of cardiac arrhythmias leading to cardiac death, e.g. cardiac excitability, conduction velocity and refractoriness. Several murine models harbouring human gene mutations leading to electrical and structural cardiac disorders have been developed, including channelopathies (long QT syndrome), familial conduction disorders, cardiomyopathies and other inherited cardiac disorders. This article reviews the results of the main genetically modified mice addressing the genesis of cardiac arrhythmias and sudden cardiac death.
PB IMR Press
SN 2768-6701
YR 2007
FD 2007-01-01
LK https://hdl.handle.net/20.500.14352/125491
UL https://hdl.handle.net/20.500.14352/125491
LA eng
NO Juan Tamargo,  Ricardo Caballero,  Lucía Núñez,  Ricardo Gómez,  Miguel Vaquero,  Eva Delpón. Genetically engineered mice as a model for studying cardiac arrhythmias. Front. Biosci. (Landmark Ed) 2007, 12(1), 22–38. https://doi.org/10.2741/2046
NO Comisión Interministerial de Ciencia y Tecnología (España)
NO Comunidad Autónoma de Madrid
NO Red RECAVA
DS Docta Complutense
RD 10 abr 2026