RT Journal Article
T1 Dramatic increase in lymph node dendritic cell number during infection by the mouse mammary tumor virus occurs by a CD62L-dependent blood-borne DC recruitment
A1 Martin, Pilar
A1 Ruiz Ruiz, Sara
A1 Martínez del Hoyo, Gloria
A1 Anjuère, Fabienne
A1 Hernández Vargas, Héctor
A1 López-Bravo, María
A1 Fernández-Ardavín Castro, Carlos
AB Despite the information dealing with the differential phenotype and function of the main mouse dendritic cell (DC) subpopulations, namely, CD8alpha(-) and CD8alpha(+) DCs, their origin and involvement in antiviral immune responses in vivo are still largely unknown. To address these issues, this study used the changes occurring in DC subpopulations during the experimental infection by the Swiss (SW) strain of the mouse mammary tumor virus (MMTV). MMTV(SW) induced an 18-fold increase in lymph node DCs, which can be blocked by anti-CD62L treatment, concomitant with the presence of high numbers of DCs in the outer cortex, in close association with high endothelial venules. These data suggest that the DC increase caused by MMTV(SW) infection results from the recruitment of blood-borne DCs via high endothelial venules, by a CD62L-dependent mechanism. In addition, skin sensitization assays indicate that MMTV(SW) infection inhibits epidermal Langerhans cell migration to the draining lymph node. Moreover, data on the kinetics of MMTV(SW)-induced expansion of the different DC subsets support the hypothesis that CD8(-) and CD8(+) DCs represent different maturation stages of the same DC population, rather than myeloid- and lymphoid-derived DCs, respectively, as previously proposed. Finally, the fact that DCs were infected by MMTV(SW) suggests their participation in the early phases of infection.
PB American Society of Hematology
SN 0006-4971
YR 2002
FD 2002-02-15
LK https://hdl.handle.net/20.500.14352/130804
UL https://hdl.handle.net/20.500.14352/130804
LA eng
NO Pilar Martı́n, Sara Ruiz Ruiz, Gloria Martı́nez del Hoyo, Fabienne Anjuère, Héctor Hernández Vargas, Marı́a López-Bravo, Carlos Ardavı́n; Dramatic increase in lymph node dendritic cell number during infection by the mouse mammary tumor virus occurs by a CD62L-dependent blood-borne DC recruitment. Blood 2002; 99 (4): 1282–1288. doi: https://doi.org/10.1182/blood.V99.4.1282
NO European Commission
NO Comunidad de Madrid (España)
NO Ministerio de Ciencia y Tecnología (España)
DS Docta Complutense
RD 14 jul 2026