RT Journal Article
T1 Repeated intraperitoneal injection of liposomes containing phosphatidic acid and cardiolipin reduce β-amyloid levels in APP/PS1 transgenic mice
A1 Ordóñez Gutiérrez, Lara
A1 Wandosell, Francisco
AB The accumulation of extracellular amyloid-beta (Aβ) peptide and intracellular neurofibrillary tangles in the brain are two major neuropathological hallmarks of Alzheimer's disease (AD). It is thought that an equilibrium exists between Aβ in the brain and in the peripheral blood and thus, it was hypothesized that shifting this equilibrium towards the blood by enhancing peripheral clearance might reduce Aβ levels in the brain: the 'sink effect'. We tested this hypothesis by intraperitoneally injecting APP/PS1 transgenic mice with small unilamellar vesicles containing either phosphatidic acid or cardiolipin over 3weeks. This treatment reduced significantly the amount of Aβ in the plasma and the brain levels of Aβ were lighter affected. Nevertheless, this dosing regimen did modulate tau phosphorylation and glycogen synthase kinase 3 activities in the brain, suggesting that the targeting of circulating Aβ may be therapeutically relevant in AD.
PB Elsevier
YR 2014
FD 2014-11-14
LK https://hdl.handle.net/20.500.14352/114301
UL https://hdl.handle.net/20.500.14352/114301
LA eng
NO Ordóñez-Gutiérrez L, Re F, Bereczki E, Ioja E, Gregori M, Andersen AJ, Antón M, Moghimi SM, Pei JJ, Masserini M, Wandosell F. Repeated intraperitoneal injections of liposomes containing phosphatidic acid and cardiolipin reduce amyloid-β levels in APP/PS1 transgenic mice. Nanomedicine. 2015 Feb;11(2):421-30. doi: 10.1016/j.nano.2014.09.015. Epub 2014 Nov 14. PMID: 25461285.
NO European Community's Seventh Framework Programme
NO CIBERNED
NO Plan Nacional DGCYT
DS Docta Complutense
RD 12 abr 2025