RT Journal Article
T1 Ophthalmologic Psychophysical Tests Support OCT Findings in Mild Alzheimer's Disease
A1 García Martín, Elena Salobrar
A1 Hoz Montañana, María Rosa De
A1 Rojas López, María Blanca
A1 Ramírez Sebastián, Ana Isabel
A1 Salazar Corral, Juan José
A1 Yubero Pancorbo, Raquel
A1 Gil Gregorio, Pedro
A1 Triviño Casado, Alberto
A1 Ramírez Sebastián, José Manuel
AB Purpose. To analyze in mild Alzheimer's disease (MAD) patients, GDS-4 (Reisberg Scale), whether or not some psychophysical tests (PTs) support OCT macular findings in the same group of MAD patients reported previously. Methods. Twenty-three MAD patients and 28 age-matched control subjects with mean Mini Mental State Examination of 23.3 and 28.2, respectively, with no ocular disease or systemic disorders affecting vision were included. Best-corrected visual acuity (VA), contrast sensitivity (CS) (3, 6, 12, and 18 cpds), color perception (CP), and perception digital test (PDT) were tested in one eye of each patient. Results. In comparison with the controls, MAD patients presented (i) a significant decrease in VA, PDT, and CS for all spatial frequencies analyzed, especially the higher ones, and (ii) a significant increase in unspecific errors on the blue axis (P < 0.05 in all instances). In MAD patients, a wide a ROC curve was plotted in all PTs. Conclusions. In MAD, CS, VA, and the tritan axis in CP were impaired. The PTs with the greatest predictive value are the higher spatial frequencies in CS and tritan unspecific errors in CP. PT abnormalities are consistent with the structural findings reported in the same MAD patients using OCT.
PB HINDAWI PUBLISHING CORPORATION
SN 2090-004X
YR 2015
FD 2015-05-20
LK https://hdl.handle.net/20.500.14352/24070
UL https://hdl.handle.net/20.500.14352/24070
LA eng
NO García Martín, E. S., Hoz Montañana, M. R., Rojas López, M. B. et al. «Ophthalmologic Psychophysical Tests Support OCT Findings in Mild Alzheimer’s Disease». Journal of Ophthalmology, vol. 2015, 2015, pp. 1-10. DOI.org (Crossref), https://doi.org/10.1155/2015/736949.
NO Copyright © 2015 Elena Salobrar-Garcia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Ministerio de Educación, Formación Profesional y Deportes (España)
NO Redes Temáticas de Investigación Cooperativa: OFTARED
DS Docta Complutense
RD 5 abr 2025