RT Journal Article
T1 Slow-wave activity in the S1HL cortex is contributed bydifferent layer-specific field potential sources duringdevelopment
A1 Ortuño, Tania
A1 López-Madrona, Victor J.
A1 Makarova, Julia
A1 Tapia-Gonzalez, Silvia
A1 Muñoz Céspedes, Alberto
A1 DeFelipe, Javier
A1 Herreras, Óscar
AB Spontaneous correlated activity in cortical columns is criticalfor postnatal circuit refinement.We used spatial discriminationtechniques to explore the late maturation of synaptic pathways through the laminar distribution of the field potential (FP) generators underlying spontaneous and evoked activities ofthe S1HL cortex in juvenile (P14 –P16) and adult anesthetized rats. Juveniles exhibit an intermittent FP pattern resembling Up/Down states in adults, but with much reduced power and different laminar distribution. Whereas FPs in active periods are dominated by a layer VI generator in juveniles, in adults a developing multipart generatortakes over, displaying current sinks in middle layers (III–V). The blockade of excitatory transmission in upper and middle layers of adults recovered the juvenile-like FP profiles. In additiontothe layer VI generator, a gamma-specific generator in supragranular layers wasthe same in both age groups.While searching for dynamical coupling among generators in juveniles we found significant cross-correlation in one-half of the tested pairs, whereas excessive coherence hindered their efficient separation in adults. Also, potentials evoked by tactile and electrical stimuli showed different short-latency dipoles between the two age groups, and the juveniles lacked the characteristic long latency UP state currents in middle layers. In addition, the mean firing rate of neurons was lower in juveniles. Thus, cortical FPs originate from different intracolumnar segments as they become active postnatally. We suggest that although some cortical segments are active early postnatally, a functional sensory-motor control relies on a delayed maturation and network integration of synaptic connections in middle layers.
PB Society for Neuroscience
SN 0270-6474, ESSN: 1529-2401
YR 2019
FD 2019-11-06
LK https://hdl.handle.net/20.500.14352/5963
UL https://hdl.handle.net/20.500.14352/5963
LA eng
NO Unión Europea. Horizonte 2020
NO Ministerio de Economía y Competitividad (MINECO)
NO Ministerio de Ciencia e Innovación (MICINN)
DS Docta Complutense
RD 14 may 2026