RT Journal Article
T1 Extraction of antibiotics identified in the EU Watch List 2020 from hospital wastewater using hydrophobic eutectic solvents and terpenoids
A1 Gutiérrez Sánchez, Pablo
A1 Rodríguez Llorente, Diego
A1 Navarro, Pablo
A1 Águeda Maté, Vicente Ismael
A1 Álvarez Torrellas, Silvia
A1 García, Juan
A1 Larriba Martínez, Marcos
AB The increasing consumption of pharmaceuticals, along with the ineffectiveness of conventional wastewater treatment, has resulted in an increased presence of these pollutants in both drinking water supplies and aquatic environments. The potential adverse health effects and environmental impact of these chemicals are drawing the attention of several bodies around the world. For instance, some antibiotics such as ciprofloxacin, trimethoprim, and sulfamethoxazole have been included in the most recent European Surface Water Watch List under the EU Water Framework Directive (Decision 2020/1161). The present work proposes the use of terpenoids and eutectic solvents, as effective and green solvents with low toxicity, for multicomponent liquid-liquid extraction of ciprofloxacin, trimethoprim, and sulfamethoxazole from ultrapure water and hospital wastewater. The COSMO-RS method was used for a predictive initial solvent screening. Thymol, carvacrol, eutectic solvents (thymol + fatty acids), and conventional solvents (methyl isobutyl ketone and ethyl acetate) were selected to be used in the experiments. The influence of the volume S/F ratio, aqueous matrix, and pH was analysed. Conventional solvents show significantly lower overall extraction yields than those observed for eutectic solvents and terpenoids at any pH and matrix. Carvacrol presented the most favourable conditions, reaching overall extraction yields above 98.0% (98.9% for trimethoprim, 99.5% for ciprofloxacin, and 97.0% for sulfamethoxazole) with hospital wastewater at pH 5.0 and S/F ratio of 1.00. Carvacrol showed a feasible operating in a continuous extraction column at room temperature, providing effective reuse and regeneration processes in this study.The increasing consumption of pharmaceuticals, along with the ineffectiveness of conventional wastewater treatment, has resulted in an increased presence of these pollutants in both drinking water supplies and aquatic environments. The potential adverse health effects and environmental impact of these chemicals are drawing the attention of several bodies around the world. For instance, some antibiotics such as ciprofloxacin, trimethoprim, and sulfamethoxazole have been included in the most recent European Surface Water Watch List under the EU Water Framework Directive (Decision 2020/1161). The present work proposes the use of terpenoids and eutectic solvents, as effective and green solvents with low toxicity, for multicomponent liquid-liquid extraction of ciprofloxacin, trimethoprim, and sulfamethoxazole from ultrapure water and hospital wastewater. The COSMO-RS method was used for a predictive initial solvent screening. Thymol, carvacrol, eutectic solvents (thymol + fatty acids), and conventional solvents (methyl isobutyl ketone and ethyl acetate) were selected to be used in the experiments. The influence of the volume S/F ratio, aqueous matrix, and pH was analysed. Conventional solvents show significantly lower overall extraction yields than those observed for eutectic solvents and terpenoids at any pH and matrix. Carvacrol presented the most favourable conditions, reaching overall extraction yields above 98.0% (98.9% for trimethoprim, 99.5% for ciprofloxacin, and 97.0% for sulfamethoxazole) with hospital wastewater at pH 5.0 and S/F ratio of 1.00. Carvacrol showed a feasible operating in a continuous extraction column at room temperature, providing effective reuse and regeneration processes in this study.
PB Elsevier
SN 1383-5866
YR 2022
FD 2022-02-01
LK https://hdl.handle.net/20.500.14352/71778
UL https://hdl.handle.net/20.500.14352/71778
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Comunidad de Madrid
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 12 abr 2025