RT Journal Article
T1 Maternal Folic Acid Deficiency Is Associated to Developing Nasal and Palate Malformations in Mice
A1 Maldonado Bautista, Estela
A1 Martínez Sanz, Elena
A1 Partearroyo, Teresa
A1 Varela Moreiras, Gregorio
A1 Pérez De Miguelsanz, María Juliana
AB Craniofacial development requires extremely fine-tuned developmental coordination of multiple specialized tissues. It has been evidenced that a folate deficiency (vitamin B9), or its synthetic form, folic acid (FA), in maternal diet could trigger multiple craniofacial malformations as oral clefts, tongue, or mandible abnormalities. In this study, a folic acid-deficient (FAD) diet was administered to eight-week-old C57/BL/6J female mouse for 2–16 weeks. The head symmetry, palate and nasal region were studied in 24 control and 260 experimental fetuses. Our results showed a significant reduction in the mean number of fetuses per litter according to maternal weeks on FAD diet (p < 0.01). Fetuses were affected by cleft palate (3.8%) as well as other severe congenital abnormalities, for the first time related to maternal FAD diet, as head asymmetries (4.6%), high arched palate (3.5%), nasal septum malformed (7.3%), nasopharynx duct shape (15%), and cilia and epithelium abnormalities (11.2% and 5.8%). Dysmorphologies of the nasal region were the most frequent, appearing at just four weeks following a maternal FAD diet. This is the first time that nasal region development is experimentally related to this vitamin deficiency. In conclusion, our report offers novel discoveries about the importance of maternal folate intake on midface craniofacial development of the embryos. Moreover, the longer the deficit lasts, the more serious the consequent effects appear to be.
PB MPDI
SN 2072-6643
YR 2021
FD 2021-01-16
LK https://hdl.handle.net/20.500.14352/7044
UL https://hdl.handle.net/20.500.14352/7044
LA eng
NO Maldonado Bautista, E., Martínez Sanz, E., Partearroyo, T. et al. «Maternal Folic Acid Deficiency Is Associated to Developing Nasal and Palate Malformations in Mice». Nutrients, vol. 13, n.o 1, enero de 2021, p. 251. Crossref, https://doi.org/10.3390/nu13010251.
NO Instituto de Salud Carlos III
NO Ministerio de Sanidad
NO Fundación Universitaria San Pablo CEU/Banco de Santander
DS Docta Complutense
RD 10 may 2025