%0 Journal Article
%A Gomez, Alexia
%A Sánchez-Román Rojas, Inés
%A Gomez, Jose
%A Naudí, Alba
%A Pushparaj, Charumati
%A Portero-Otín, Manuel
%A López Torres, Mónica
%A Pamplona, Reinald
%A Barja De Quiroga Losada, Gustavo
%T Reduction in mitochondrialmembrane peroxidizability index and protein lipoxidation levels in therat heart after ß-adrenergic receptor signaling interruption with the ß-blocker atenolol
%D 2013
%@ 1697-4271
%U https://hdl.handle.net/20.500.14352/97863
%X A new mammalian longevity model based on ß-adrenergic signaling interruption at the level of adenylyl cyclase has reported decreased bone and heart aging and mean and maximum	longevity increases in AC5KO mice (1). We decided to mimic this model in male Wistar rats treated with	the ß-blocker atenolol in the drinking water and to check if an oxidative stress	decrease could be	involved.	 Atenolol treatment did not	modify heart	 mitROS generation rate and mitDNA oxidative damage but	significantly	decreased global	peroxidizability	index	of	mitochondrial membranes, as well as protein lipoxidation, probably mediated by changes	 in elongases and desaturases activities.
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