RT Journal Article
T1 Reduction in mitochondrialmembrane peroxidizability index and protein lipoxidation levels in therat heart after ß-adrenergic receptor signaling interruption with the ß-blocker atenolol
T2 Reducción en el índice de peroxidizabilidad de la membrana mitocondrial y niveles de lipoxidación proteícos en el corazón de la rata después de la interrupción de la señalización del receptor betaadrenérgico con el betabloqueante atenolol
A1 Gomez, Alexia
A1 Sánchez-Román Rojas, Inés
A1 Gomez, Jose
A1 Naudí, Alba
A1 Pushparaj, Charumati
A1 Portero-Otín, Manuel
A1 López Torres, Mónica
A1 Pamplona, Reinald
A1 Barja De Quiroga Losada, Gustavo
AB A new mammalian longevity model based on ß-adrenergic signaling interruption at the level of adenylyl cyclase has reported decreased bone and heart aging and mean and maximum	longevity increases in AC5KO mice (1). We decided to mimic this model in male Wistar rats treated with	the ß-blocker atenolol in the drinking water and to check if an oxidative stress	decrease could be	involved.	 Atenolol treatment did not	modify heart	 mitROS generation rate and mitDNA oxidative damage but	significantly	decreased global	peroxidizability	index	of	mitochondrial membranes, as well as protein lipoxidation, probably mediated by changes	 in elongases and desaturases activities.
SN 1697-4271
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/97863
UL https://hdl.handle.net/20.500.14352/97863
LA eng
NO An. Real	Acad. Farm. Vol 79, Nº4 (2013),	pag. 613-633
NO Generalitat de Catalunya
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 9 abr 2025