RT Journal Article T1 Functional meat products as oxidative stress modulators: a review A1 Macho González, Adrián A1 Bastida Codina, Sara A1 Garcimartín Álvarez, Alba A1 López-Oliva Muñoz, María Elvira A1 González, Pilar A1 Benedí González, Juana María A1 González Muñoz, María José A1 Sánchez Muniz, Francisco José AB High meat consumption has been associated with increased oxidative stress mainly due to the generation of oxidized compounds in the body, such as malondialdehyde, 4-hydroxy-nonenal, oxysterols, or protein carbonyls, which can induce oxidative damage. Meat products are excellent matrices for introducing different bioactive compounds, to obtain functional meat products aimed at minimizing the pro-oxidant effects associated with high meat consumption. Therefore, this review aims to summarize the concept and preparation of healthy and functional meat, which could benefit antioxidant status. Likewise, the key strategies regarding meat production and storage as well as ingredients used (e.g., minerals, polyphenols, fatty acids, walnuts) for developing these functional meats are detailed. Although most effort has been made to reduce the oxidation status of meat, newly emerging approaches also aim to improve the oxidation status of consumers of meat products. Thus, we will delve into the relation between functional meats and their health effects on consumers. In this review, animal trials and intervention studies are discussed, ascertaining the extent of functional meat products' properties (e.g., neutralizing reactive oxygen species formation and increasing the antioxidant response). The effects of functional meat products in the frame of diet–gene interactions are analyzed to 1) discover target subjects that would benefit from their consumption, and 2) understand the molecular mechanisms that ensure precision in the prevention and treatment of diseases, where high oxidative stress takes place. Long-term intervention-controlled studies, testing different types and amounts of functional meat, are also necessary to ascertain their positive impact on degenerative diseases. PB Elsevier SN 2161-8313 YR 2021 FD 2021-02-12 LK https://hdl.handle.net/20.500.14352/92264 UL https://hdl.handle.net/20.500.14352/92264 LA eng NO Ministerio de Educación, Cultura y Deporte de España DS Docta Complutense RD 1 sept 2024