RT Journal Article
T1 Morphometric and neurochemical alterations found in l-BMAA treated rats
A1 Munck García, Estefanía de
A1 Muñoz Sáez, Emma
A1 Gómez Miguel, Begoña
A1 Solas Alados, Mª Teresa
A1 Martínez, Ana
A1 Arahuetes, Rosa María
AB Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscle paralysis that reflects the motoneurons’ degeneration. Several studies support the relationship between β-N-methylamino-L-alanine (L-BMAA), a neurotoxic amino acid produced by cyanobacteria and diatoms, and the sporadic occurrence of ALS and other neurodegenerative diseases. Therefore, the study of its neurotoxicity mechanisms has assumed great relevance in recent years.Recently, our research team has proposed a sporadic ALS animal model by L-BMAA administration in rats, which displays many pathophysiological features of human ALS. In this paper, we deepen the characterization of this model corroborating the occurrence of alterations present in ALS patients such as decreased muscle volume, thinning of the motor cortex, enlarged brain's lateral ventricles, and alteration of both bulbar nuclei and neurotransmitters’ levels. Therefore, we conclude that L-BMAA treated rats could be a good model which mimics degenerative features that ALS causes in humans.
PB Elsevier
SN 1382-6689
YR 2015
FD 2015-05
LK https://hdl.handle.net/20.500.14352/23212
UL https://hdl.handle.net/20.500.14352/23212
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Fundación Española para el Fomento de la Investigación de la Esclerosis Lateral Amiotrófica (España)
DS Docta Complutense
RD 7 abr 2025