%0 Journal Article
%A Carrasco Perera, José Luis
%A Díaz Marsa, Marina Francisca
%A Pastrana, Jose I.
%A Molina, Rosa
%A Brotons, Loreto
%A López-Ibor Alcocer, María Inés
%A López-Ibor Aliño, Juan José
%T Hypothalamic-pituitary-adrenal axis response in borderline personality disorder without post-traumatic features
%D 2018
%@ 0007-1250
%@ 1472-1465
%U https://hdl.handle.net/20.500.14352/116874
%X Hypothalamic–pituitary–adrenal (HPA) axis sensitivity was investigated in 32 non-medicated patients with borderline personality disorder without comorbid post-traumatic syndromes and in 18 normal individuals using a modified dexamethasone suppression test (0.25 mg). Enhanced cortisol suppression was found in the patients v. controls (P < 0.05) and the percentage of participant's with non-suppression was smaller in the patient (34%) than in the control group (89%) (P < 0.01). Baseline cortisol levels in the patients were also lower than in the controls (P < 0.05). The 0.25 mg dexamethasone suppression test reveals increased feedback inhibition of the HPA in borderline personality disorder.
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