RT Journal Article
T1 Sevoflurane Prevents Liver Inflammatory Response Induced by Lung Ischemia-Reperfusion
A1 Rancán, Lisa
A1 Huerta Martínez, Luis Javier
A1 Cusati, Gabriel
A1 Erquicia, Iñaki
A1 Isea, Jesús
A1 Paredes Royano, Sergio Damián
A1 García Martín, M. Cruz
A1 Garutti Martínez, Ignacio
A1 Simón Adiego, Carlos María
A1 Vara Ameigeiras, Elena María
AB Background: Transplants cause ischemia-reperfusion (IR) injury that can affect distant organs. Liver is particularly sensitive to IR injury. The present randomized experimental study was designed to investigate a possible protective effect of sevoflurane against liver inflammatory response to lung IR in a lung upper lobe left autotransplant model.Methods: Two groups (sevoflurane and control) of eight swines each were submitted to upper lobe left lung autotransplant. Hypnotic maintenance was performed with sevoflurane 3% or propofol 8 to 10 mg/kg per hr until pneumonectomy was done; then propofol was used for all animals. Blood and liver samples were taken in four different moments: prepneumonectomy, prereperfusion, 10 min postreperfusion and 30 min postreperfusion to measure levels of interleukin (IL)-1β, IL-10, tumor necrosis factor (TNF)-α, monocyte chemotactic protein (MCP)-1, nuclear factor (NF)-κB, C-reactive protein, ferritin and caspase 3. Non-parametric test was used to find statistical meaning.Results: Lung IR markedly increased the expression of TNF-α, IL-1β, MCP-1, NF-κB and caspase activity in control livers compared with basal levels, whereas liver IL-10 expression decreased 10 and 30 min post-reperfusion. Sevoflurane significantly decreased TNF-α, IL-1β, MCP-1, NF-κB liver expression and caspase 3 activity. Sevoflurane also reverted the lung IR-induced decrease in IL-10 expression.Conclusions: The present results indicate that lung IR caused hepatic injury. Sevoflurane attenuated liver injury in a model of upper lobe left lung autotransplant in pigs.
PB Wolters Kluwer Health, Inc.
SN 0041-1337
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/93192
UL https://hdl.handle.net/20.500.14352/93192
LA eng
NO Rancan, Lisa1,5; Huerta, Luis2; Cusati, Gabriel3; Erquicia, Iñaki3; Isea, Jesús2; Paredes, Sergio D.4; García, Cruz1; Garutti, Ignacio3; Simón, Carlos2; Vara, Elena1. Sevoflurane Prevents Liver Inflammatory Response Induced by Lung Ischemia-Reperfusion. Transplantation 98(11):p 1151-1157, December 15, 2014. | DOI: 10.1097/TP.0000000000000408
NO Ministerio de Ciencia y Educación (España)
DS Docta Complutense
RD 18 jul 2024