RT Journal Article
T1 Corneal Properties in Primary Open Angle Glaucoma Assessed Through Scheimpflug Corneal Topography and Densitometry
A1 Molero Senosiain, Mercedes
A1 Morales Fernández, Laura
A1 Sáenz Francés, Federico
A1 Perucho González, Lucía
A1 García Bella, Javier
A1 García Feijoo, Julián
A1 Martínez De La Casa Fernández-Borrella, José María
AB Purpose: To compare corneal topography and densitometry measurements in patients with primary open angle glaucoma (POAG) and healthy subjects.Patients and Methods: 200 eyes of 75 patients with POAG and 125 healthy controls underwent corneal topography and densitometry (Oculus Pentacam HR). The data compared in the two groups were: anterior chamber angle (ACA), depth (ACD) and volume (ACV), keratometry (K minimum, K maximum and K mean), central corneal thickness (CCT), central anterior elevation (CAE), anterior elevation apex (AEA), maximum anterior elevation (MAE) and posterior elevation apex (PEA). Densitometry measurements were made at three depths on a 12▒mm-diameter circle divided into 4 concentric rings (0-2▒mm, 2-6▒mm, 6-10▒mm and 10-12▒mm). The diagnostic capacity of the corneal variables was assessed through the areas under the receiver operator characteristics (ROC) curve (AUC).Results: The corneal density of practically all depth layers and total corneal density were significantly higher in the POAG than control group (P<0.05). Total corneal density was positively correlated with age (r=0.623; P<0.001) and also showed a good diagnostic capacity for glaucoma (AUC=0.617; IC 95% [0.541-0.697]; P<0.001). In a multiple linear regression designed to assess its relationship with age, gender, CCT and Km, age emerged as a significant confounder both in controls (coef. 0.315; P<0.001; 95% CI [0.246-0.384]) and patients (coef. 0.370; P<0.001; 95% CI [0.255-0.486]).Conclusion: Corneal densitometry measurements showed a good diagnostic capacity for POAG suggesting this type of examination could have clinical applications in the diagnosis and management of glaucoma.
PB Wolters Kluwer Health
SN 1057-0829, 1536-481X
YR 2020
FD 2020-12-10
LK https://hdl.handle.net/20.500.14352/7753
UL https://hdl.handle.net/20.500.14352/7753
LA eng
NO Molero Senosiain, M., Morales Fernández, L., Sáenz Francés, F. et al. «Corneal Properties in Primary Open-Angle Glaucoma Assessed Through Scheimpflug Corneal Topography and Densitometry». Journal of Glaucoma, vol. 30, n.o 5, mayo de 2021, pp. 444-50. DOI.org (Crossref), https://doi.org/10.1097/IJG.0000000000001770.
DS Docta Complutense
RD 12 abr 2025