RT Journal Article
T1 Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro
A1 Rodriguez Pacheco, Francisca
A1 Garrido Novelle, Marta
A1 Vazquez, María
A1 García Escobar, Eva
A1 Soriguer, Federico
A1 Rojo Martínez, Gemma
A1 García Fuentes, Eduardo
A1 Malagón, María del Mar
A1 Diéguez, Carlos
AB The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function and also regulates growth hormone (GH) secretion in rat adenopituitary cells cultures with the adipokine. Although adipose tissue is the primary source of resistin, it is also expressed in other tissues, including the pituitary. The aim of this study is to investigate the possible action of resistin on the lipid metabolism in the pituitary gland in vivo (rats in two different nutritional status, fed and fast, treated with resistin on acute and a chronic way) and in vitro (adenopituitary cell cultures treated with the adipokine). Here, by a combination of in vivo and in vitro experimental models, we demonstrated that central acute and chronic administration of resistin enhance mRNA levels of the lipid metabolic enzymes which participated on lipolysis and moreover inhibiting mRNA levels of the lipid metabolic enzymes involved in lipogenesis. Taken together, our results demonstrate for the first time that resistin has a regulatory role on lipid metabolism in the pituitary gland providing a novel insight in relation to the mechanism by which this adipokine can participate in the integrated control of lipid metabolism.
PB Wiley
SN 0962-9351
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/94905
UL https://hdl.handle.net/20.500.14352/94905
LA eng
NO Rodriguez-Pacheco, F., et al. «Resistin Regulates Pituitary Lipid Metabolism and Inflammation In Vivo and In Vitro». Mediators of Inflammation, vol. 2013, 2013, pp. 1-8.  https://doi.org/10.1155/2013/479739.
NO Acknowledgments: Sara Borrell Postdoctoral program; BFU 2011 and CIBER Obesidad y Nutricion (Instituto de Salud Carlos Tercero (ISCIII), Ministerio de Ciencia e Innovacion). Juan de la Cierva Program (Ministerio de Educación y Ciencia).
NO Instituto de Salud Carlos III
NO Ministerio de Ciencia e Innovación (España)
NO Ministerio de Educación y Ciencia (España)
DS Docta Complutense
RD 9 abr 2025