RT Journal Article
T1 Estrogen receptor ligands counteract cognitive deficits caused by androgen deprivation in male rats
A1 Lagunas García, Luisa Natalia
A1 Calmarza-Font, Isabel
A1 Grassi, Daniela
A1 Garcia-Segura, Luis
AB Androgen deprivation causes impairment of cognitive tasks in rodents and humans, and this deficit can be reverted by androgen replacement therapy. Part of the effects of androgens in the male may be mediated by their local metabolism to estradiol or 3-alpha androstanediol within the brain and the consequent activation of estrogen receptors. In this study we have assessed whether the administration of estradiol benzoate, the estrogen receptor β selective agonist diarylpropionitrile or the estrogen receptor α selective agonist propyl pyrazole triol affect performance of androgen-deprived male Wistar rats in the cross-maze test. In addition, we tested the effect of raloxifene and tamoxifen, two selective estrogen receptor modulators used in clinical practice. The behavior of the rats was assessed 2 weeks after orchidectomy or sham surgery. Orchidectomy impaired acquisition in the cross-maze test. Estradiol benzoate and the selective estrogen receptor β agonist significantly improved acquisition in the cross-maze test compared to orchidectomized animals injected with vehicle. Raloxifene and tamoxifen at a dose of 1mg/kg, but not at doses of 0.5 or 2mg/kg, also improved acquisition of orchidectomized animals. Our findings suggest that estrogenic compounds with affinity for estrogen receptor β and selective estrogen receptor modulators, such as raloxifene and tamoxifen, may represent good candidates to promote cognitive performance in androgen-deprived males.
PB Elsevier
SN 0018-506X
YR 2011
FD 2011
LK https://hdl.handle.net/20.500.14352/95216
UL https://hdl.handle.net/20.500.14352/95216
LA eng
NO Lagunas, Natalia, et al. «Estrogen Receptor Ligands Counteract Cognitive Deficits Caused by Androgen Deprivation in Male Rats». Hormones and Behavior, vol. 59, n.o 4, abril de 2011, pp. 581-84. https://doi.org/10.1016/j.yhbeh.2011.02.014.
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 11 abr 2025