RT Journal Article
T1 Synaptic components are required for glioblastoma progression in Drosophila
A1 Losada Pérez, María De La Paloma
A1 Hernández García-Moreno, Mamen
A1 García-Ricote, Irene
A1 Casas-Tintó, Sergio
A2 Perrimon, Norbert
AB Glioblastoma (GB) is the most aggressive, lethal and frequent primary brain tumor. It originates from glial cells and is characterized by rapid expansion through infiltration. GB cells interact with the microenvironment and healthy surrounding tissues, mostly neurons and vessels. GB cells project tumor microtubes (TMs) contact with neurons, and exchange signaling molecules related to Wingless/WNT, JNK, Insulin or Neuroligin-3 pathways. This cell to cell communication promotes GB expansion and neurodegeneration. Moreover, healthy neurons form glutamatergic functional synapses with GB cells which facilitate GB expansion and premature death in mouse GB xerograph models. Targeting signaling and synaptic components of GB progression may become a suitable strategy against glioblastoma. In a Drosophila GB model, we have determined the post-synaptic nature of GB cells with respect to neurons, and the contribution of post-synaptic genes expressed in GB cells to tumor progression. In addition, we document the presence of intratumoral synapses between GB cells, and the functional contribution of pre-synaptic genes to GB calcium dependent activity and expansion. Finally, we explore the relevance of synaptic genes in GB cells to the lifespan reduction caused by GB advance. Our results indicate that both presynaptic and postsynaptic proteins play a role in GB progression and lethality.
PB Public Library of Science
SN 1553-7404
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/94808
UL https://hdl.handle.net/20.500.14352/94808
LA eng
NO Losada-Pérez M, Hernández García-Moreno M, García-Ricote I, Casas-Tintó S (2022) Synaptic components are required for glioblastoma progression in Drosophila. PLoS Genet 18(7): e1010329. https://doi.org/10.1371/journal.pgen.1010329
NO This research was supported by PID2019-110116GB-100 grant from the Spanish Ministerio de Ciencia e Innovación to S C-T and by a Postdoctoral Fellowship from the Comunidad de Madrid (2016-T2-BMD-1295) to M L-P. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
NO Ministerio de Ciencia e Innovación (España)
NO Comunidad de Madrid
NO Ministerio de Ciencia e Innovación (España)
NO Comunidad de Madrid
DS Docta Complutense
RD 30 dic 2025