RT Journal Article
T1 Dependence of induced biological damage on the energy distribution and intensity of clinical Intra-operative radiotherapy electron beams
A1 Colmenares, Rafael
A1 Carrión Marchante, Rebeca
A1 Martín, M. Elena
A1 Salinas Muñoz, Laura
A1 García Bermejo, María Laura
A1 Oller, Juan C.
A1 Muñoz, Antonio
A1 Blanco Ramos, Francisco
A1 Rosado Vélez, Jaime
A1 Lozano, Ana I.
A1 Álvarez, Sofía
A1 García Vicente, Feliciano
A1 García, Gustavo
AB The survival fraction of epithelial HaCaT cells was analysed to assess the biological damage caused by intraoperative radiotherapy electron beams with varying energy spectra and intensities. These conditions were achieved by irradiating the cells at different depths in water using nominal 6 MeV electron beams while consistently delivering a dose of 5 Gy to the cell layer. Furthermore, a Monte Carlo simulation of the entire irradiation procedure was performed to evaluate the molecular damage in terms of molecular dissociations induced by the radiation. A significant agreement was found between the molecular damage predicted by the simulation and the damage derived from the analysis of the survival fraction. In both cases, a linear relationship was evident, indicating a clear tendency for increased damage as the averaged incident electron energy and intensity decreased for a constant absorbed dose, lowering the dose rate. This trend suggests that the radiation may have a more pronounced impact on surrounding healthy tissues than initially anticipated. However, it is crucial to conduct additional experiments with different target geometries to confirm this tendency and quantify the extent of this effect.
PB MDPI
SN 1661-6596
YR 2023
FD 2023-06-28
LK https://hdl.handle.net/20.500.14352/104825
UL https://hdl.handle.net/20.500.14352/104825
LA eng
NO Colmenares, R.; Carrión-Marchante, R.; Martín, M.E.; Salinas Muñoz, L.; García-Bermejo, M.L.; Oller, J.C.; Muñoz, A.; Blanco, F.; Rosado, J.; Lozano, A.I.; et al. Dependence of Induced Biological Damage on the Energy Distribution and Intensity of Clinical Intra-Operative Radiotherapy Electron Beams. Int. J. Mol. Sci. 2023, 24, 10816. https://doi.org/10.3390/ijms241310816
NO Ministerio de Ciencia e Innovación (España)
NO Ministerio de Economía y Competitividad (España)
NO Instituto de Salud Carlos III
NO European Commission
DS Docta Complutense
RD 29 abr 2025