RT Journal Article
T1 DNA-Modulated and Mechanoresponsive Excitonic Couplings Reveal Chiroptical Correlation of Conformation, Tension, and Dynamics of DNA Self-Assembly
A1 Mo, Xiaomei
A1 Li, Huacheng
A1 Tang, Pan
A1 Hao, Yaya
A1 Dong, Bingqian
A1 Marazuela Lamata, María Dolores
A1 Gómez Gómez, María Milagros
A1 Zhu, Xianfeng
A1 Li, Qian
A1 Lora Maroto, Beatriz
A1 Jiang, Shuoxing
A1 Fan, Chunhai
A1 Lan, Xiang
AB Study of the conformational and mechanical behaviors of biomolecular assemblies is vital to the rational design and realization of artificial molecular architectures with biologically relevant functionality. Here, we revealed DNA-modulated and mechanoresponsive excitonic couplings between organic chromophores and verified strong correlations between the excitonic chiroptical responses and the conformational and mechanical states of DNA self-assemblies irrespective of fluorescence background interference. Besides, the excitonic chiroptical effect allowed sensitive monitoring of DNA self-assembled nanostructures due to small molecule bindings or DNA strand displacement reactions. Moreover, we developed a new chiroptical reporter, a DNAtemplated dimer of an achiral cyanine5 and an intrinsically chiral BODIPY, that exhibited unique multiple-split spectral line shape of exciton-coupled circular dichroism, largely separated response wavelengths, and enhanced anisotropy dissymmetry factor (g-factor). These results shed light on a promising chiroptical spectroscopic tool for studying biomolecular recognition and binding, conformation dynamics, and soft mechanics in general.
PB American Chemical Society
SN 1530-6984
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/92251
UL https://hdl.handle.net/20.500.14352/92251
LA eng
NO DNA-Modulated and Mechanoresponsive Excitonic Couplings Reveal Chiroptical Correlation of Conformation, Tension, and Dynamics of DNA Self-Assembly Xiaomei Mo, Huacheng Li, Pan Tang, Yaya Hao, Bingqian Dong, M. Dolores Marazuela, M. Milagros Gomez-Gomez, Xianfeng Zhu, Qian Li, Beatriz L. Maroto, Shuoxing Jiang, Chunhai Fan, and Xiang Lan Nano Letters 2023 23 (24), 11734-11741 DOI: 10.1021/acs.nanolett.3c03652
DS Docta Complutense
RD 18 mar 2026