RT Journal Article
T1 Fueling the cell division cycle
A1 Salazar Roa, María
A1 Malumbres, Marcos
AB Cell division is a complex process with high energy demands. However, how cells regulate the generation of energy required for DNA synthesis and chromosome segregation is not well understood. Recent data suggest that changes in mitochondrial dynamics and metabolic pathways such as oxidative phosphorylation (OXPHOS) and glycolysis crosstalk with, and are tightly regulated by, the cell division machinery. Alterations in energy availability trigger cell-cycle checkpoints, suggesting a bidirectional connection between cell division and general metabolism. Some of these connections are altered in human disease, and their manipulation may help in designing therapeutic strategies for specific diseases including cancer. We review here recent studies describing the control of metabolism by the cell-cycle machinery.
PB Elsevier
SN 0962-8924
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/95047
UL https://hdl.handle.net/20.500.14352/95047
LA eng
NO María Salazar-Roa, Marcos Malumbres, Fueling the Cell Division Cycle, Trends in Cell Biology, Volume 27, Issue 1, 2017, Pages 69-81, ISSN 0962-8924, https://doi.org/10.1016/j.tcb.2016.08.009.
NO Salazar-Roa, Maria as first author.M.S.R. thanks the Asociación Española contra el Cáncer (AECC) for support. Research in the laboratory of the authors is supported by grants from the Comunidad de Madrid (S2010/BMD-2470), Spanish Ministry of Economy and Competitiveness (BFU2014-52125-REDT, SAF2014-57791-REDC, PCIN-2015-007 and SAF2015-69920-R cofunded by ERDF-EU), Worldwide Cancer Research (WCR no. 15-0278), and the European Commission Seventh Framework Programme (MitoSys project HEALTH-F5-2010-241548 and NEURON8-Full-815-094).
NO Ministerio de Economía y Competitividad (España)
NO European Commission
NO Comunidad de Madrid
NO Worldwide Cancer Research
NO Asociación Española contra el Cáncer
DS Docta Complutense
RD 17 abr 2025