RT Journal Article
T1 The Role of Nitric Oxide and Hydrogen Sulfide in Urinary Tract Function
A1 Leite Fernandes, Vitor Samuel
A1 Hernández Rodríguez, Medardo Vicente
AB This MiniReview focuses on the role played by nitric oxide (NO) and hydrogen sulfide (H2 S) in physiology of the upper and lower urinary tract. NO and H2 S, together with carbon monoxide, belong to the group of gaseous autocrine/paracrine messengers or gasotransmitters, which are employed for intra- and intercellular communication in almost all organ systems. Because they are lipid-soluble gases, gaseous transmitters are not constrained by cellular membranes, so that their storage in vesicles for later release is not possible. Gasotransmitter signals are terminated by falling concentrations upon reduction in production that are caused by reacting with cellular components (essentially reactive oxygen species and NO), binding to cellular components or diffusing away. NO and, more recently, H2 S have been identified as key mediators in neurotransmission of the urinary tract, involved in the regulation of ureteral smooth muscle activity and urinary flow ureteral resistance, as well as by playing a crucial role in the smooth muscle relaxation of bladder outlet region. Urinary bladder function is also dependent on integration of inhibitory mediators, such as NO, released from the urothelium. In the bladder base and distal ureter, the co-localization of neuronal NO synthase with substance P and calcitonin gene-related peptide in sensory nerves as well as the existence of a high nicotinamide adenine dinucleotide phosphate-diaphorase activity in dorsal root ganglion neurons also suggests the involvement of NO as a sensory neurotransmitter.
PB Wiley Online Library
YR 2016
FD 2016-10
LK https://hdl.handle.net/20.500.14352/114436
UL https://hdl.handle.net/20.500.14352/114436
LA eng
NO Fernandes, Vítor S., y Medardo Hernández. «The Role of Nitric Oxide and Hydrogen Sulfide in Urinary Tract Function». Basic & Clinical Pharmacology & Toxicology, vol. 119, n.o S3, octubre de 2016, pp. 34-41. DOI.org (Crossref), https://doi.org/10.1111/bcpt.12565.
NO Ministerio de Ciencia e Innovación (España)
NO Universidad Complutense de Madrid
NO Fundação para a Ciência e Tecnología, Ministério da Educação e Ciência, Portugal
DS Docta Complutense
RD 23 abr 2025