%0 Journal Article
%A Lozano, Blanca
%A Teresa, Javier
%A Fernández López, Israel
%A Tortosa, Mariola
%T Cyclopropylmethyl Boronic Esters as General Reagents in Transition-Metal Catalyzed Homoallylation Reactions
%D 2025
%U https://hdl.handle.net/20.500.14352/131542
%X Herein we disclose the use of cyclopropylmethyl boronates as general reagents in Negishi-type homoallylation reactions. This strategy provides a novel approach to generate enantioenriched homoallyl-Zn species through boron-to-zinc transmetalation. Subsequent sp2–sp3 cross-coupling offers a platform for the preparation of arenes, ketones, and 1,5-dienes containing a chiral homoallylic scaffold. The method has been applied to the late-stage functionalization of known drugs and the preparation of precursors of biologically relevant compounds. Mechanistic experiments and DFT calculations provide insight into the transmetalation/ring-opening sequence.
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